[{"id":7,"date":"2018-03-29T18:18:25","date_gmt":"2018-03-29T18:18:25","guid":{"rendered":"http:\/\/www.pvamu.edu\/ccsb\/?page_id=7"},"modified":"2019-12-15T21:31:42","modified_gmt":"2019-12-15T21:31:42","slug":"currently-funded-projects","status":"publish","type":"page","link":"https:\/\/www.pvamu.edu\/ccsb\/currently-funded-projects\/","title":{"rendered":"Current Projects"},"content":{"rendered":"

Discovery of individualized therapeutic vulnerability in cancer, enabled by single cell transcriptomic profiling<\/em><\/strong>: We propose to test and further optimize GPU-EDDY as a statistically robust and efficient application to address the rigorous computational requirements for a deployable single-cell RNAseq analysis platform.\u00a0 Specifically, scRNAseq profiles of gliomablastoma patients and patient-derived xenograft (PDX) will be analyzed to identify potential therapeutic mediators for each tumor. This approach further strengthens from ongoing Glioma Precision Medicine efforts at TGen, which primarily rely on molecular profiling of bulk tumor.
\nNVIDIA Foundation \u2013 Compute the Cure<\/a>\u00a0\/ TGen |\u00a0Seungchan Kim (PI)<\/p>\n

HBCU-RISE: Bridging Quantitative Science with Biological Research: Jumpstarting Computational Systems Biology Research at PVAMU<\/em><\/strong>: The research objective of this proposal is to study and analyze the dynamic evolution of drug\/cell interaction using biomedical big data including both public domain data and dynamic time series data from systematic drug perturbations experiments. The educational goal is to enhance the PhD program in ECE department and broad participation in computational biology at PVAMU to improve students\u2019 retention and competence.
\nNSF\/HRD NSF-1736196<\/a> |\u00a0Lijun Qian (PI)<\/p>\n

CRII: Modeling and Analysis of Genetic Regulatory Networks under Drug Perturbation<\/strong><\/em><\/a>\u2028<\/strong>: This project targets the dynamics of Genetic Regulatory Networks (GRNs) under drug perturbation using hybrid systems, in order to quantify drug effectiveness regarding different dosing regimens, optimal target(s), and combinational therapy.
\nNSF\/IIS NSF-1464387<\/a> |\u00a0Xiangfang Li (PI)<\/p>\n

Credentialing murine models for glioblastoma preclinical drug development<\/em><\/strong>: Our goal is to credential murine models of glioblastoma against the human disease using comprehensive molecular and drug response profiling. Models will be molecularly matched to human disease subtypes and used to develop rational combination therapies that combat drug resistance mechanisms.
\nNIH\/NCI 1R01CA204-136-01A1<\/a> \/ UNC |\u00a0Ryan Miller (PI)<\/p>\n

Reprogramming of Transcriptional Circuitry to Control Pancreatic Cancer<\/em><\/strong>: The Dream Team believes that the biological machinery involved is controlled through hot spots in a cell\u2019s DNA called Super Enhancers (SE), which control not only the cancer cell, but also surrounding non-cancerous cells, upon which the cancer cells rely for support.\u00a0 The Dream Team aims to develop new approaches to reset malfunctioning SEs in pancreatic tumors thereby dialing-up the sensitivity to chemotherapy and to anti-cancer immune cells and pushing pancreatic tumors into lasting remission.
\nSU2C-Cancer Research UK-Lustgarten Foundation<\/a> \/ TGen |\u00a0Dan von Hoff (PI)<\/p>\n

exRNA signatures Predict Outcomes after brain injury<\/em><\/strong>: The goal of this project is to identify extracellular RNA biomarkers in blood and cerebrovascular fluid (CSF) of outcome for individuals suffering aneurysmal subarachnoid hemorrhage (aSAH) and newborns with intraventricular hemorrhage (IVH).
\nNIH\/NINDS 1UH2TR000891<\/a> \/ TGen |\u00a0Kendall Van Keuren-Jensen (PI)<\/p>\n

Noncoding RNA Biomarkers for Noninvasive and Early Detection of Pancreatic Cancer<\/em><\/strong>: The project will perform a comprehensive and genome-wide evaluation of cell-free and exosomal microRNA biomarkers in serum samples as potential noninvasive biomarkers for the early detection of pancreatic cancers and precancerous lesions. Successful identification of such biomarkers will exert a substantial diagnostic and prognostic impact on the management of this fatal disease.
\nNIH\/NCI 1U01CA214254-01<\/a> \/ BSWRI-TGen |\u00a0Ajay Goel and Dan von Hoff (multi-PIs)<\/p>\n","protected":false},"excerpt":{"rendered":"

Discovery of individualized therapeutic vulnerability in cancer, enabled by single cell transcriptomic profiling: We propose to test and further optimize GPU-EDDY as a statistically robust and efficient application to address the rigorous computational requirements for a deployable single-cell RNAseq analysis platform.\u00a0 Specifically, scRNAseq profiles of gliomablastoma patients and patient-derived xenograft (PDX) will be analyzed to […]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"side-navigation.php","meta":{"_acf_changed":false,"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","_content_title_display":"","footnotes":""},"class_list":["post-7","page","type-page","status-publish","hentry"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/pages\/7","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/comments?post=7"}],"version-history":[{"count":0,"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/pages\/7\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/media?parent=7"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":4,"date":"2018-03-29T18:07:27","date_gmt":"2018-03-29T18:07:27","guid":{"rendered":"http:\/\/www.pvamu.edu\/ccsb\/home\/"},"modified":"2019-12-15T21:31:42","modified_gmt":"2019-12-15T21:31:42","slug":"home","status":"publish","type":"page","link":"https:\/\/www.pvamu.edu\/ccsb\/","title":{"rendered":"CCSB@PVAMU"},"content":{"rendered":"

There is a new website for CCSB@PVAMU<\/a>.<\/p>\n

https:\/\/ccsb.pvamu.edu<\/a><\/p>\n<\/div>

<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"side-navigation.php","meta":{"_acf_changed":false,"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","_content_title_display":"","footnotes":""},"class_list":["post-4","page","type-page","status-publish","hentry"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/pages\/4","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/comments?post=4"}],"version-history":[{"count":0,"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/pages\/4\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pvamu.edu\/ccsb\/wp-json\/wp\/v2\/media?parent=4"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}]