CARC – Scientist Profile – Gary R. Newton
Gary Newton Ph. D.
Research Scientist Leader (Animal Systems Research)
Post Doctoral., University of Florida (Reproductive Biology)
Ph.D., University of Kentucky (Animal Science)
M.S., University of Kentucky (Animal Science)
B.Sc., State University of New York, College at Geneseo (Biology)
Animals System, Reproductive Performance, Genetic Improvement Animal Genome
Expertise and Current Research Interests
For all mammalian pregnancies the first 30 days is the most critical stage for survival of the conceptus (i.e. the early embryo and associated fetal membranes). Of all human and domestic animal pregnancies that fail, the largest proportion is lost during the earliest stages of conceptus - uterine interactions. We study the molecular mechanisms maternal and fetal tissues use to communicate with each other when they come into contact during the first 30 days of pregnancy. This type of cell recognition is important for events leading to establishment of pregnancy and formation of the placenta. Understanding these developmentally regulated events may lead to better treatment and diagnostic strategies for infertility, novel approaches to contraception and better methods for controlled breeding in livestock.
Office: P.O. Box 519; MS 2008, AGRL, RM 158, Prairie View, TX 77446
Phone: (936) 261-5036
Five most closely related to proposal project
Woldesenbet, S., Newton, G.R. 2003. Comparison of proteins synthesized by polarized caprine oviductal epithelial cells and oviductal explants in vitro. Theriogenology 60:533-543.
Woldesenbet, S., Garcia, R.F., Igbo, N., Leak, J., Lewis, S.K. and Newton, G.R. 2004. Lectin receptors for endometrial H-type 1 antigen on goat conceptuses. Am. J. Reprod. Immunol. 52:74-80.
Joyce, M.M., González, J.F., Lewis, S.K., Woldesenbet, S., Burghardt, R.C., Newton, G.R., and Johnson, G.A. 2005. Caprine uterine and placental osteopontin expression is distinct among epitheliochorial implanting species. Placenta 26:160-170.
Tekin A., Padua M.B., Newton, G.R., and Hansen P.J. 2005. Identification and cloning of caprine uterine serpin. Mol. Reprod. Develop. 70:262-270.
Lewis, S.K., Farmer, J.L., Burghardt, R.C., Newton, G.R., Johnson, G.A., Adelson,D.L., Bazer, F.W. and Spencer, T.S. 2007. Galectin-15 (LGALS15): A gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment. Biol. Reprod. 77:1027-1036.
Five other significant publications
Newton, G.R., D.W. Weise, J.A. Bowen, S. Woldesenbet and R.C. Burghardt. 1998. Regulation of protein and prostaglandin secretion in polarized primary cultures of caprine uterine epithelial cells. In Vitro Cell. Develop. Biol. Anim. 34:578-584.
Johnson, G.A, R.C. Burghardt, T.E. Spencer, G.R. Newton, T.L. Ott and F.W. Bazer. 1999. Ovine osteopontin:II. Osteopontin and avß3 integrin expression in the uterus and conceptus during the peri-implantation period. Biol. Reprod. 61:892-899.
Johnson G.A., Burghardt, R.C., Newton G.R., Bazer, F.W. and Spencer, T.E. 1999. Development and characterization of immortalized ovine endometrial cell lines. Biol. Reprod. 61:1324-1330.
Powell, J.K., S.R. Glasser, S. Woldesenbet, R.C. Burghardt and G.R. Newton. 2000. Expression of carbohydrate antigens in the goat uterus during early pregnancy and on steroid treated polarized uterine epithelial cells in vitro. Biol. Reprod. 62:277-284.
Woldesenbet, S., Green, T., Newton, G.R. 2002. H-type 1 carbohydrate antigen expression by ovine endometrial cells. In Vitro Cell. Dev. Biol. Anim. 38:358-364.
Member of the NIGMS-NIH Minority Biomedical Research Support Review Sub-Committee (1997 – 2001); Editorial Board – Journal of Animal Science (2005 – 2007); USDA-NIFA Agriculture & Food Research Initiative (AFRI) Animal Reproduction Program Panelist 2007, 2008, 2011 and 2013; Associate Editor - Reproductive Physiology, Small Ruminant Research; 2012 – present; NIH-USDA Special Emphasis Program Panalist- Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Species; Program Panelist 2012
Collaborators & Other Affiliations
Fuller Bazer (Professor), David Forrest (Professor), Nancy H. Ing (Associate Professor), Department of Animal Sciences, Texas A&M University; Robert C. Burghardt (Professor),
Greg Johnson (Associate Professor), Integrate Veterinary Biosciences, Texas A&M University
Graduate and Postdoctoral Advisors
Ray H. Dutt, and Lee A. Edgerton, University of Kentucky (Graduate); Peter Hansen and William Thatcher, University of Florida (Postdoctoral)
1989 – present, Research Scientist, Cooperative Agricultural Research Center, Prairie View A&M University, Research Scientist Leader since 2008. Member, Interdisciplinary Faculty of Reproductive Biology, Texas A&M University (Vice Chairman 2007-2010). Adjunct Associate Professor, Department of Veterinary Integrated Biosciences and Department of Animal Science, Texas A&M University.
1976 – 1978 Peace Corps Volunteer in Rural Extension and Development, State of Kedah. Federation of Malaysia
Grant Funded (last 5 years)
2009 – 2011: USDA – CSREES #2009-34136-119794, “Characterization of Apical Plasma Membrane Proteins Carrying the H-Type 1 Antigen”. $87,635.
2010 - 2013: USDA – CSREES #2010-02310, “Biological Role of the H-Type 1 antigen in Mediating Conceptus-Endometrial Interactions”. $186,134
Teaching (list of courses taught during the last 5 years)
Ansc 5513 – Physiology of Reproduction.